硫普罗宁治疗慢性乙型肝炎的临床疗效对照研究

目的：评价硫普罗宁治疗慢性乙型肝炎的效果及安全性。方法：慢性乙型肝炎80例,随机分为两组。治疗组40例,以硫普罗宁0.2g加入5%葡萄糖溶液250ml中静滴,1次/日,连续治疗4周,对照组40例,以甘草酸二铵150mg加入5%葡萄糖溶液250ml中静滴,1次/日,连续治疗4周;同时分别监测肝功能指标：丙氨酸氨基转移酶（ALT）,天冬氨酸转移酶（AST）、总蛋白（TP）、总胆红素（TBi）、肝纤维化指标（HA、PCⅢ）及凝血酶原活动度（PTA）等,并进行比较分析。结果：硫普罗宁治疗组较对照组在肝功能复常方面显示良好的治疗效应,可使转氨酶及HA明显下降,两组显效率分别为50%（20/40）和25%（10/40）,总有效率为85%（34/40）和47.5%（19/40）,两组比较差异有显著性（p〈0.01）。结论：短期临床研究提示硫普罗宁治疗慢性乙型肝炎,可明显改善肝脏功能,有抗纤维化作用,且副作用少,疗效显著。

Clinical efficacy of tiopronin on chronic hepatitis B

Objective： To evaluate the therapeutic effect and safety oftiopronin on chronic hepatitis B （CHB）. Methods： 80 cases CHB were devided randomly into two groups on the average. The treatment group was treated by tiopronin 0.2g with intravenous drip once a day for four weeks, The control group was treated by diammonium glycyrrhizinate 150mg with intravenous drip once a day for four weeks, and liver fimction including alanine aminotransferase （ALT）and aspartate aminotransferase （AST）activities, the levels of serum total protein （TP）, total bilirubin （TBi）, hepatic fibrosis index and prothrombin activity （PTA） were measured respectively. The results of two groups were compared. Results： the therapeutic effect of the treatment group were evidently prior to the control group in recovering liver function and clinical symptoms improved obviously in treatment group .Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase and HA. The obvious effective rates were 50% （20/40）in the treatment group, and25%（ 10/40）in the control group, respectively. The total effective rates were 85% （34/40）in the former and 47.5% （19/40）in the later, respectively. Significant difference in therapeutic effect was found between the two groups （p〈0.01）. Conclusion： The present data suggest that tiopronin improves the liver function with few side effect and has a good therapeutic effect and anti-fibrosis on patients with CHB during short-term study.