癫痫与海马结构的改变

癫痫作为一种严重危害人类健康的常见病、多发病，其致病机理至今尚未阐明。30—60％的患者药物治疗无效，称“难治性癫痫”。随着现代医学的发展，外科手术的开展对于癫痫患者治疗也没有满意的效果。这就对于我们探求癫痫患者病灶的起源有了更深层次的要求。大量动物实验表明，海马作为中枢神经系统的重要结构不仅同学习、记忆、情绪等密切相关，还同癫痫的发生发展有着重要的联系。本文就大脑可塑性与癫痫的关系进行综述。

Epilepsy： alteration of hippocampal formation

Epilepsy is a sort of common and frequently-occurring disease. Mechanisms of it are not well understood. Most of them are temporal lobe epilepsy （TLE）. Defining precisely the site of seizure onset has important implications for our understanding of the pathophysiology of temporal lobe epilepsy. A relatively large number of patients for whom seizure control are incomplete. Reevalua- tion of the extent of the pathology, from animal models, suggests that the seizure focus extends, at least in some cases, beyond the hip- pocampus. Numerous studies in animal models imply that hippocampal neurogenesis is important for functions such as learning, memory, and mood. Additional studies suggest that hippocampal neurogenesis is very sensitive to physiological and pathological stimuli, such as acute seizures. In this paper was discussed the alteration ofhippocampal formation in chronic temporal lobe epilepsy.