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A homopolymer of the potent antitumor drug 2'-deoxy-5-fluorouridylate |
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| Authors: | V Amarnath T L Miller A D Broom |
| Abstract: | Poly(5-fluoro-2'-deoxyuridylic acid) was synthesized and its properties were compared with those of poly(dT) and poly(dU). It readily complexed with poly(dA). The 1:1 complex melted at about 20 degrees C lower than poly(dA) . poly(dT). A triple-stranded helix, poly(dA) . 2 poly(dF5U) was formed only in high salt (2.0 M NaCl). |
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