Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man |
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| Authors: | S Bissbort K Bender T F Wienker K H Grzeschik |
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| Institution: | (1) Institut für Humangenetik und Anthropologie der Universität Freiburg, Albertstr. 11, D-7800 Freiburg, Federal Republic of Germany;(2) Institut für Humangenetik der Universität Münster, Vesaliusweg 12-14, D-4400 Münster, Federal Republic of Germany |
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| Abstract: | Summary A specific staining procedure for the demonstration of S-adenosylhomocysteine hydrolase (SAAH, EC 3.3.1.1) is given. The enzyme has a broad tissue distribution and is also present in erythrocytes. The SAHH gene is polymorphic in the population of southwest Germany with two common alleles: SAHH
*1=0.96 and SAHH
*1=0.04. Family studies resulted in the expected segregation ratios. No evidence for close linkage with a total of 25 marker loci was found. But information from human mouse somatic-cell hybrids led to the localization of the SAHH gene to human chromosome 20, thereby confirming the findings of Hershfield and Francke (1982).Dedicated to Professor Dr. P. E. Becker on the occasion of his 75th birthday |
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