A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II) |
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| Authors: | Kierat Radoslaw M Krämer Roland |
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| Affiliation: | 1. Institute of Chemistry, University of Silesia, ul. Szkolna 9, PL-40007, Katowice, Poland;2. School of Pharmacy, The Queens University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK;3. Faculty of Chemistry, University of Wrocław, 14 Joliot-Curie Street, 50-383, Wrocław, Poland;1. School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China;2. School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China;1. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China;2. College of Chemical Engineering, Xiangtan University, Xiangtan 411105, PR China;3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, PR China;1. Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China;2. College of Chemical Engineering, Xiangtan University, Xiangtan, 411105, PR China;3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, 410082, PR China |
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| Abstract: | Bis(picolinoyl)fluorescein, a new fluorogenic and chromogenic probe for monitoring the esterase activity of metal ions, has been synthesized. The probe is highly selective for Cu2+ and is applicable both to quantification of the free ion and detection of esterolytic activity of Cu bound to organic ligands or biomolecules, with a detection limit of 100 nM by fluorimetry. |
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