黄酮类化合物促进癌细胞凋亡的分子机理研究进展

黄酮类化合物是一类低分子天然植物成分,这类化合物具有共同的母核C6-C3-C6。黄酮类化合物具有抗炎、抗氧化、抗肿瘤、改善心血管功能等生物活性。国内、外的大量研究表明,促进肿瘤细胞的凋亡是其抗肿瘤的机理之一。随着分子生物学技术的发展,黄酮类化合物诱导肿瘤细胞凋亡的分子机理也逐渐被阐明。本文简要综述国内外黄酮类化合物诱导癌细胞凋亡的分子机理研究进展。

The Mechanism of Carcinoma Cells' Apoptosis Induced by Flavones

The flavonoid is a kind of low molecular natural plant ingredient,and this kind of compound has common parent nucleus C6-C3-C6.The flavonoid has anti-biological activity and so on the inflammation,anti-oxidation,anti-tumor,improvement cardiovascular function.The domestic and foreign massive research indicated that the promotion tumor cell apoptosis is one of its anti-tumor mechanisms.Along with the development of molecular biology technology,the molecular mechanism which the flavonoid induce tumor cell apoptosis also gradual was expounded.This review was focused on the mechanisms of apoptosis induced by favonoid.