Cellular and molecular mechanisms of neuronal migration in neocortical development |
| |
Authors: | Honda Takao Tabata Hidenori Nakajima Kazunori |
| |
Affiliation: | Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. |
| |
Abstract: | The complicated mammalian brain structure arises from accurate movements of neurons from their birthplace to their final locations. Detailed observation of this migration process by various methods revealed that neuronal migration is highly motile and that there are different modes of migration. Moreover, mouse mutants or human disorders that disrupt normal migration have provided significant insights into molecular pathways that control the neuronal migration. Although our knowledge is still fragmentary, it is becoming clear that various molecules are participating in this process. In this review, we outline about the cellular and molecular mechanisms of neuronal migration in the cerebral cortex. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|