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The effect of a histidine operator-constitutive mutation on UV-induced mutability within the histidine operon ofSalmonella typhimurium
Authors:D J Savi&#; and D T Kanazir
Institution:(1) Laboratory for Biochemistry, Institute for Nuclear Sciences “Boris Kidrič”, Vinča, P.O. Box 522, 11000 Beograd, Yugoslavia;(2) Department for Molecular Biology, Faculty of Sciences, University of Beograd, Yugoslavia
Abstract:Summary The presence of the histidine operator-constitutive mutationhis01242 increases UV-induced mutability within the histidine operon ofSalmonella typhimurium. The rate of reversion ofhisC andhisF ochre and frameshift mutants is increased 5- to 8-fold when these mutations are coupled withhis01242 which causes 15-fold derepression of the operon. The effect does not extend to the whole chromosome since the rate of UV-induced mutability at the unlinked streptomycin locus is the same in the strains carryinghis0 + orhis01242 alleles. The same phenomenon was observed in Hcr strains.
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