The effect of a histidine operator-constitutive mutation on UV-induced mutability within the histidine operon ofSalmonella typhimurium |
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Authors: | D J Savi and D T Kanazir |
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Institution: | (1) Laboratory for Biochemistry, Institute for Nuclear Sciences “Boris Kidrič”, Vinča, P.O. Box 522, 11000 Beograd, Yugoslavia;(2) Department for Molecular Biology, Faculty of Sciences, University of Beograd, Yugoslavia |
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Abstract: | Summary The presence of the histidine operator-constitutive mutationhis01242 increases UV-induced mutability within the histidine operon ofSalmonella typhimurium. The rate of reversion ofhisC andhisF ochre and frameshift mutants is increased 5- to 8-fold when these mutations are coupled withhis01242 which causes 15-fold derepression of the operon. The effect does not extend to the whole chromosome since the rate of UV-induced
mutability at the unlinked streptomycin locus is the same in the strains carryinghis0
+ orhis01242 alleles. The same phenomenon was observed in Hcr− strains. |
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