Retinal pigment epithelium contains a distinctive strychnine-binding site |
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| Authors: | Stephen C Bondy John M Werdel R Theodore Fletcher Gerald J Chader |
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| Institution: | (1) Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, P.O. Box 12233, 27709 Research Triangle Park, North Carolina;(2) Laboratory of Vision Research National Eye Institute, National Institutes of Health, 20205 Bethesda, Maryland |
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| Abstract: | Membranes prepared from the retinal pigment epithelium of several species possess a specific site which binds 3H]strychnine. This binding has a somewhat lower affinity and a much greater density than the corresponding interaction in the hindbrain or neural retina. Binding is not greatly altered in the presence of 10–3 M glycine,l-alanine,  -alanine, taurine, or serine. Thus, the receptor does not resemble the classical glycine receptor of the hindbrain and spinal cord. This new type of binding site appears to be confined to the pigment epithelial layer of the retina. |
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