Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK. Jason_Witherington@GSK.com
Abstract:
A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4.