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SITE TO SITE VARIATION IN THE SOAP CHAMBER TEST
Authors:MB FINKEY  MC GACULA  JR  JK MILLER
Institution:The Dial Technical Center 15101 N. Scottsdale Rd. Scottsdale, AZ 85254
Abstract:This investigation was conducted to examine the contribution of intrasite variation on the volar forearm to the overall variation in irritation under the conditions of a soap chamber test. Six sites on each forearm of human volunteers were patched with an eight percent aqueous solution of a commercial bar soap, known to be moderately irritating. Clinical evaluations of the sites were made independently by two judges twenty-four hours after the first patch application and six hours following applications conducted over the next four consecutive days. Site to site variability was estimated to be only 3.2% of the total variance component. It is suggested that as with any biologic assay, this variance can be reduced by an increase in the number of panelists.
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