Synthesis and biological evaluation of gambierol analogues |
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| Authors: | Fuwa Haruhiko Kainuma Noriko Satake Masayuki Sasaki Makoto |
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| Affiliation: | Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity. |
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