Neocarzinostatin: an antitumor protein a preliminary x-ray diffraction study. |
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Authors: | L C Sieker L H Jensen T S Samy |
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Affiliation: | Department of Biological Structure, School of Medicine University of Washington, Seattle, Washington 98195 USA;Sidney Farber Cancer Center, Harvard Medical School Boston, Massachusetts 02115 USA |
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Abstract: | The antitumor protein, neocarzinostatin, has been crystallized and examined by X-ray diffraction. Crystals of this globular protein are of space group P212121 with cell parameters a = 27.4Å, b = 33.9Åand c = 102.0Å. There is one molecule of approximately 27Ådiameter per asymmetric unit. Crystals soaked in a K2HgI4 solution give diffraction patterns significantly different from native crystal diffraction patterns. |
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