The effect of aging on the mineral status of female SAMP1 and SAMR1 |
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| Authors: | Akemi Morita Dilber Abdireyim Mieko Kimura Yoshinori Itokawa |
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| Institution: | (1) Department of Public Health, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan;(2) Xinjiang Medical University, Urumqi, Xinjiang, China;(3) Takeda Research Institute of Life Science, Minami-cho, Chudoji, Shimogyo-ku, Kyoto, Japan;(4) Fukui Prefectural University, Matsuoka-cho, Yoshida-gun, Fukui, Japan |
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| Abstract: | The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and
SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial
diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, sodium, and potassium concentrations in blood, liver, kidney,
brain, and tibia of the mice were determined. The copper concentration in the brain was significantly increased with age in
SAMP1 and SAMR1. In addition, the brain copper levels in SAMP1 were significantly higher than that in SAMR1 at respective
ages. The calcium concentration in the kidney was significantly increased with age, but the copper and phosphorus concentrations
significantly decreased with age in SAMP1 and SAMR1. In the liver of SAMR1, all minerals measured in this study except for
sodium and potassium were significantly decreased with age. In addition, all mineral concentrations in the liver of 2-mo-old
mice in SAMR1 except for copper and sodium were markedly higher than those in SAMP1 of the same age. These results suggest
that the genetic factor is related to the age-associated mineral changes in tissues. |
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| Keywords: | Aging female mice SAM iron zinc copper calcium magnesium phosphorus sulfur sodium potassium |
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