Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684 |
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Authors: | Yoo Jin Cheol Kim Jun Ho Ha Jung Wan Park Nae Soo Sohng Jae Kyung Lee June Woo Park Seong Chan Kim Mi Sun Seong Chi Nam |
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Institution: | Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea. |
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Abstract: | Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique. |
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