Cellular immune response to acetylcholine receptors in murine experimental autoimmune myasthenia gravis: inhibition with monoclonal anti-I-A antibodies |
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Authors: | P Christadoss J Lindstrom N Talal |
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Affiliation: | 1. Department of Medicine, Division of Clinical Immunology, The University of Texas Health Science Center at San Antonio, The Audie L. Murphy Veterans Administration Hospital, San Antonio, Texas 78284 USA;2. Salk Institute, La Jolla, California 92112 USA |
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Abstract: | Gene(s) at the I-A subregion of the murine major histocompatibility complex influence susceptibility to experimental autoimmune myasthenia gravis. C57Bl/6 mice immunized with acetylcholine receptors (AChR) in complete Freund's adjuvant demonstrated cellular and humoral immune responses to AChR. They developed muscle weakness characteristic of myasthenia gravis and demonstrated a reduction in the muscle AChR content. The kinetics of AChR-specific lymphocyte proliferation generally correlate with anti-AChR antibody response. AChR-specific lymphocyte proliferation was also observed in C57Bl/6 splenocytes after secondary immunization with AChR. The in vitro cellular reactivity to AChR in experimental autoimmune myasthenia gravis (EAMG) mice (C57Bl/6) was suppressed by monoclonal anti-I-Ab antibodies directed against private (Ia20) or public (Ia8) specificities, suggesting a critical role for these Ia determinants in the cellular immune response to AChR in murine EAMG. |
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Keywords: | To whom correspondence should be addressed. Department of Medicine Division of Clinical Immunology The University of Texas Health Science Center at San Antonio 7703 Floyd Curl Dr. San Antonio Tex. 78284. |
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