Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets |
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Authors: | Weingartl Hana Czub Markus Czub Stefanie Neufeld James Marszal Peter Gren Jason Smith Greg Jones Shane Proulx Roxanne Deschambault Yvonne Grudeski Elsie Andonov Anton He Runtao Li Yan Copps John Grolla Allen Dick Daryl Berry Jody Ganske Shelley Manning Lisa Cao Jingxin |
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Institution: | National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2. |
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Abstract: | Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis. |
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