| 综述——新型纳米生物材料的研发：模板法制备羟基磷灰石纳米结构微球及其机制探讨 |
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| 引用本文： | 肖东琴,匙峰,姚宁,张成栋,段可,翁杰.综述——新型纳米生物材料的研发：模板法制备羟基磷灰石纳米结构微球及其机制探讨[J].生物化学与生物物理进展,2013,40(10):935-947. |
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| 作者姓名： | 肖东琴 匙峰 姚宁 张成栋 段可 翁杰 |
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| 作者单位： | 西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031,西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031,西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031,西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031,西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031,西南交通大学材料科学与工程学院，材料先进技术教育部重点实验室，成都 610031 |
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| 基金项目： | 国家重点基础研究发展计划(973)资助项目(2012CB933602)，国家自然科学基金面上项目(51172188)，四川省科技支撑计划资助项目(2010FZ0048)，中央高校基本科研业务费专项资金资助项目(SWJTU11ZT11)，四川省青年科技基金创新团队项目(2010JQ0081)和2013年西南交通大学博士创新基金资助项目 |
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| 摘 要： | 羟基磷灰石作为人体和动物骨骼的主要无机成分，被广泛应用于人体硬组织的修复和替换．而羟基磷灰石微球因具有比表面积大、流动性好等优点，成为生物医学领域的重要研究对象．本文重点论述了采用软/硬模板合成羟基磷灰石纳米结构微球的方法、原理，以及微球和纳米结构的形成机理．提出了羟基磷灰石纳米结构微球研究中存在的问题，并对其前景进行展望．
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| 关 键 词： | 羟基磷灰石，模板，微球，纳米结构，自组装 |
| 收稿时间： | 2013/6/20 0:00:00 |
| 修稿时间： | 2013/7/18 0:00:00 |
Review: Nanostructured Hydroxyapatite Microspheres by Templated Synthesis:Formation and Mechanisms |
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| XIAO Dong-Qin,CHI Feng,YAO Ning,ZHANG Cheng-Dong,DUAN Ke and WENG Jie.Review: Nanostructured Hydroxyapatite Microspheres by Templated Synthesis:Formation and Mechanisms[J].Progress In Biochemistry and Biophysics,2013,40(10):935-947. |
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| Authors: | XIAO Dong-Qin CHI Feng YAO Ning ZHANG Cheng-Dong DUAN Ke and WENG Jie |
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| Institution: | Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China,Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China,Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China,Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China,Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | As a main inorganic component of the human bone, hydroxyapatite (HA) is widely used in hard tissue repair and replacement. With high surface area and excellent fluidity, HA microspheres have gained extensive interests for biomedical applications. This article reviews the synthesis of HA microspheres with nanostructures, with a special focus on the use of soft and hard templates. The formation mechanism of these microspheres and related nanostructures are also discussed in detail. Problems in current synthesis methods are identified and the future trends of this emerging field are also discussed. |
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| Keywords: | hydroxyapatite template microspheres nanostructure self-assemble |
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