综述——纳米材料与药物输递：经皮给药中纳米制剂与皮肤的质构效关系

皮肤是人体最大的器官,也为药物的递送提供了重要途径。经皮给药是药物以皮肤为媒介,透过皮肤吸收的途径。因此,皮肤角质层是经皮给药的最大限速障碍。纳米经皮给药系统,具有提高透皮效率、缓释性、避免药物肝首过效应、减少副作用等优点,是通过纳米制剂与皮肤组织之间的相互作用实现的。其中,纳米制剂的结构和组分与其发挥皮肤促渗效用密切相关。对纳米制剂与皮肤质构效关系深入透彻的了解,有助于新型透皮纳米制剂的设计,并利用综合手段构建安全、高效、实用的经皮给药系统。

Review: Component-Structure-Effect Correlation Between Nano-Formulations and Skin Tissue in Transdermal Drug Delivery

Skin is the largest organ of human offering important pathway for drug delivery. Drug delivery through transdermal pathway have to penetrate through the skin tissue to realize absorption, thereinto, stratum corneum turns out to be the largest barrier to accomplish transdermal drug delivery. Owing to the specific interactions between nano-formulations and skin tissue, trandermal nanocarrier could provide advantages, such as improving skin penetrating efficiency, sustaining release, avoid the first-pass effect, decrease side effects, etc. The structures and components of nano-formulations play crucial roles in enhancing skin penetration. A better and more comprehensive understanding of the correlations between them is favorable not only for the design of noval transdermal nanocarrier, it is also beneficial to establish safe, efficient and functional transdermal drug delivery system.