综述——新型纳米生物材料的研发：医学纳米颗粒对类细胞膜作用的仿真研究进展

细胞膜是包围细胞质、维持细胞内部组分动态平衡的一个半透膜，参与细胞黏附、离子传导、信号传导等分子生物学过程．类细胞膜提供了有效的模型研究这些生物学过程，故而分子层面上研究医学纳米颗粒对类细胞膜的作用有助于评估纳米颗粒的生物安全性以及促进纳米颗粒的生物医学应用．本文初步探讨了医学纳米颗粒对类细胞膜作用的仿真研究进展，并在此基础上结合膜生物物理学的研究热点对后续的研究进行了展望．

Review: The Interactions of Medical Nanoparticles With Model Cell Membrane:a Review of Simulation Studies

Cell membrane is a thin semi-permeable membrane that surrounds the cytoplasm and protects the homeostasis of internal components of a cell, which is also involved in a variety of molecular biological processes such as cell adhesion, ion conductivity and cell signaling. Model cell membrane may provide an efficient alternative for studying these processes. Hence, studying the interactions between medical nanoparticles and model cell membrane may play an important role in evaluating the biosafety of nanoparticles and promoting the biomedical applications of nanoparticles. In this paper, we reviewed the recent progresses of simulation studies of the interactions between medical nanoparticles and model cell membrane. And on this basis, we proposed the future research directions considering the focuses of modern membrane biophysics.