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The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis
Authors:Maria D Mjaavatten  Désirée van der Heijde  Till Uhlig  Anne J Haugen  Halvor Nygaard  Göran Sidenvall  Knut Helgetveit  Tore K Kvien
Affiliation:1.Department of Rheumatology,Diakonhjemmet Hospital,Vinderen,Oslo,Norway;2.Department of Rheumatology,Leiden University Medical Center,Leiden,The Netherlands;3.Department of Rheumatology,?stfold Hospital Trust,Fredrikstad,Norway;4.Lillehammer Hospital for Rheumatic Diseases,Margrethe Grundtvigs vei 6,Lillehammer,Norway;5.Department of Rheumatology,Innlandet Hospital,Kongsvinger,Norway;6.Martina Hansen Hospital,B?rum Postal Terminal,Norway
Abstract:

Introduction  

We wanted to assess the importance of the levels of anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development of persistent arthritis from undifferentiated arthritis (UA), and to investigate whether there is an added predictive value for persistent arthritis in testing for both anti-CCP and IgM RF.
Keywords:
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