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Growth stimulation with honey royal jelly DIII protein of human lymphocytic cell lines in a serum-free medium |
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| Authors: | Kazuhiko Watanabe Hiroshi Shinmoto Masuko Kobori Tojiro Tsushida Kazuki Shinohara Jun Kanaeda Masami Yonekura |
| Affiliation: | (1) School of Agriculture, Ibaraki University, 3-21-1 Ami, 300-03 Ibaraki, Japan;(2) National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba, 305 Ibaraki, Japan;(3) Present address: National Research Institute of Fisheries Science, Fisheries Agency, 2-12-4 Fukuura, Kanazawa-ku, 236 Kanagawa, Japan;(4) Research Institute, API Co. Ltd., 4-23 Shinhon-machi, Kanoh, 500 Gifu, Japan |
| Abstract: | Summary The growth stimulating effects of a royal jelly protein (DIII protein) were studied. The DIII protein stimulated the growth of five human lymphocytic cell lines in serum-free conditions. Cell cycle analysis showed that U-937 cells cultured with the DIII protein did not arrest to the G1 phase. Furthermore, a binding assay using europium-labeled DIII protein showed U-937 cells had a large number of low affinity receptors on the cell surface. |
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