Dengue virus infection-enhancing and neutralizing antibody balance in children of the Philippines and Indonesia |
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| Authors: | Atsushi Yamanaka Yuko Tabuchi Kris C Mulyatno Helen Susilowati Eryk Hendrianto Soegeng Soegijanto Eiji Konishi |
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| Institution: | 1. Indonesia–Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Kampus C, UNAIR Jl. Mulyorejo, Surabaya 60115, Indonesia;2. Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan;3. Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan;1. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China;2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China;3. Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;4. Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China;1. BIKEN Endowed Department of Dengue Vaccine Development, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchahewi, Bangkok 10440, Thailand;2. Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchahewi, Bangkok 10440, Thailand;3. Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchahewi, Bangkok 10440, Thailand;1. School of Public Health and Social Work, Queensland University of Technology, Brisbane, 4059, Australia;2. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4059, Australia;3. Department of Disease Control, London School of Hygiene and Tropical Medicine, London, WC1H 9SH, UK;4. Mosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia;5. School of Biomedical Sciences, Queensland University of Technology, Brisbane, 4059, Australia;6. Center of Public Health Effort Research and Development, National Institute of Health Research and Development, Jakarta, 10560, Indonesia;7. UQ Spatial Epidemiology Laboratory, School of Veterinary Science, University of Queensland, Gatton, 4343, Australia;8. Pangandaran Unit for Health Research and Development, National Institute of Health Research and Development, Ministry of Health of Indonesia, Pangandaran, 46396, Indonesia;9. Indonesian Ministry of Health, Jakarta, 12950, Indonesia;10. Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia;1. University of Veterinary and Animal Sciences, Lahore, Pakistan;2. Institute of Public Health, Lahore, Pakistan;3. Islamia University, Bahawalpur, Pakistan;4. Naval Medical Research Unit, Cairo, Egypt;1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan, ROC;2. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC |
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| Abstract: | Dengue fever and dengue hemorrhagic fever are important diseases worldwide. Although antibody-dependent enhancement of infection has been proposed as a mechanism for increased disease severity, enhancing antibodies in endemic people have not been thoroughly investigated. Recently, we established a serological assay system to measure the balance of enhancing and neutralizing activities, which provides useful information for estimating in vivo antibody status. We measured the balance of these activities against four dengue virus (DENV) types in endemic populations, and analyzed the proportion of sera containing enhancing and neutralizing antibodies. Predominantly healthy Filipino children were used for analysis, although a population of Indonesian children was also investigated. In the Filipino population, the highest proportion of neutralizing activities was shown against DENV2, followed by DENV1. A greater proportion of sera exhibited enhancing rather than neutralizing antibodies against other virus types. Neutralizing activities were complement-dependent, while enhancing activities were complement-independent. The Indonesian population showed a similar dengue antibody status. Our results indicate that a relatively high proportion of endemic children possessed complement-independent enhancing antibodies against some DENV types. |
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