Stability analysis of mixtures of mutagenetic trees |
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Authors: | Jasmina Bogojeska Thomas Lengauer Jörg Rahnenführer |
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Institution: | 1.Max-Planck-Institut für Informatik,Saarbrücken,Germany;2.Department of Statistics,University of Dortmund,Dortmund,Germany |
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Abstract: | Background Mixture models of mutagenetic trees are evolutionary models that capture several pathways of ordered accumulation of genetic
events observed in different subsets of patients. They were used to model HIV progression by accumulation of resistance mutations
in the viral genome under drug pressure and cancer progression by accumulation of chromosomal aberrations in tumor cells.
From the mixture models a genetic progression score (GPS) can be derived that estimates the genetic status of single patients
according to the corresponding progression along the tree models. GPS values were shown to have predictive power for estimating
drug resistance in HIV or the survival time in cancer. Still, the reliability of the exact values of such complex markers
derived from graphical models can be questioned. |
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Keywords: | |
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