Analysis of the strain and stress distribution in the wall of the developing and mature rat aorta |
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| Institution: | 1. Institute of Mechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria;2. Institute of Pathology, London Hospital Medical College, London, UK;11. Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland;1. Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China;2. Key Vascular Physiology and Applied Research Laboratory, Zhengzhou, Henan, People’s Republic of China;3. Department of Physiology, Medical School of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China;4. The Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT;5. Department of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT;1. Department of Biomedicine–Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal;2. Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal;3. Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal;4. Department of Clinical Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal;5. Cardiovascular R & D Unit, Faculdade de Medicina da Universidade do Porto, Porto, Portugal;6. Department of Angiology and Vascular Surgery, Centro Hospitalar Vila Nova de Gaia e Espinho, Portugal;7. Center for Health Technology and Services Research (CINTESIS), Porto, Portugal;1. Institute of Mechanics, Department of Mechanical Engineering, TU Dortmund, Germany;2. Centro Universitario de la Defensa, Academia General Militar, Zaragoza, Spain;3. Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain;4. Laboratori de Calcul Numeric (LaCaN), Universitat Politecnica de Catalunya, Barcelona, Spain;5. Department of Anatomy, Embryology and Genetics, Veterinary Faculty, University of Zaragoza, Spain;6. Division of Solid Mechanics, Lund University, Sweden;7. 3M Deutschland GmbH, Carl-Schurz-Str. 1, D-41453 Neuss, Germany;1. Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College, London, UK;2. Section of Biomolecular Medicine, Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College, London, UK;3. Division of Vascular and Endovascular Surgery, Brigham and Women''s Hospital, Boston, MA, USA;4. Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA;5. Harvard Medical School, Boston, MA, USA;1. Vascular and Endovascular Surgery Division, Department of Surgery, Laboratory of Medical Investigation #2 (LIM 02), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil;2. Department of Pathology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil |
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| Abstract: | The variation of wall stress distribution with age in the thoracic and abdominal aortas of normotensive rats was studied. Dimensions of the zero-stress configurations were measured at the ages of 4, 8, 12, 20, and 52 weeks. Using data from previously published inflation tests, the circumferential stress-strain relationship was obtained in each age group. The calculated stress distribution showed that the average circumferential stress remained practically constant after the age of 20 weeks. The circumferential stress at the innermost part of the arterial wall was greater than the stress at the outermost part, but the difference was maintained at a moderate level with adjustments in the zero-stress configuration. It is speculated that, after the age of 20 weeks, changes in arterial geometry and rheological properties tend to maintain a constant stress distribution under varying conditions of loading. This distribution was achieved by enhanced growth at the inner part of the media in comparison with the growth at its outer margins and suggests that during development and maturity, the growth of the aorta is modulated by circumferential stress. |
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