Auditory evoked potentials in Down's syndrome |
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| Institution: | 1. Laboratório de Biofísica, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas e da Saúde, Curso de Pós-Graduação em Ciências Veterinárias, IV, UFRRJ, Seropédica, RJ, Brazil;2. Laboratório de Parasitologia, Instituto de Pesquisas Veterinárias Desidério Finamor, Eldorado do Sul, RS, Brazil;3. Laboratório de Quimioterapia Experimental em Parasitologia Veterinária, Departamento de Parasitologia Animal, Instituto de Veterinária, UFRRJ, Seropédica, RJ, Brazil;4. Laboratório de Doenças Parasitárias, Departamento de Parasitologia Animal, Instituto de Veterinária, UFRRJ, Seropédica, RJ, Brazil;5. Departamento de Epidemiologia e Saúde Pública, Instituto de Veterinária, UFRRJ, Seropédica, RJ, Brazil |
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| Abstract: | Short-, middle- and long-latency auditory evoked potentials (SAEPs, MAEPs and LAEPs) were examined in 12 subjects with Down's syndrome and in 12 age-matched normal subjects. In comparison with the normal subjects, Down subjects showed shorter latencies for SAEP peaks II, III, IV and V (and correspondingly shorter interpeak intervals I–II and I–III) so long as stimulus intensity was at least 45 dB SL. The MAEP peak Na had a longer latency in Down subjects than in normal subjects, but not the Pa latency. In passive oddball experiments for LAEPs, the latencies of all components from N1 to P3 were progressively longer in Down subjects, and the N2-P3 amplitude increased slightly between the first and fourth blocks of stimuli (whereas in the normal subjects it decreased). These alterations in auditory evoked potentials, which may correlate with cerebral alterations in organization and responsiveness responsible for deficient information processing, may constitute an electrophysiological pattern that is characteristic of Down's syndrome. |
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