Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium |
| |
Authors: | Carmen Vilchis Rocío Salceda |
| |
Institution: | (1) Departmento Neurociencias, Instituto de Fisiologia Cellular, UNAM, Apdo. Postal 70-253, C.P. 04510 Mexico, D.F., México |
| |
Abstract: | Free amino acid levels and high affinity uptake of glutamate, aspartate γ-aminobutyrate, glycine and taurine were studied
in retina and retinal pigment epithelium of streptozotocin diabetic rats. Results show that experimental diabetes produces
a generalized fall in the content of free amino acids in both retina and retinal pigment epithelium. With regard to the high
affinity uptake, in the two tissues of diabetic animals showed decreased aspartate uptake, enhanced taurine and γ-aminobutyrate
uptake, whereas that of glycine and glutamate was unchanged. These results might suggest that diabetes causes alterations
of specific amino acid transport systems and/or alterations of some cell populations. |
| |
Keywords: | Retina retinal pigment epithelium streptozotocin diabetes free amino acids uptake |
本文献已被 SpringerLink 等数据库收录! |
|