Synthesis of new phosphonamidate and phosphinamide desmuramyldipeptide analogs |
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| Authors: | Stanislav Gobec and Uro Urleb |
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| Affiliation: | (1) Faculty of Pharmacy, University of Ljubljana, A!["scaron"]("/content/h5lp778275705q88/xlarge353.gif") ker!["ccaron"]("/content/h5lp778275705q88/xlarge269.gif") eva 7, 1000 Ljubljana, Slovenia |
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| Abstract: | New desmuramyldipeptide analogs with modified peptide backbones were synthesized. The peptide bond between Ala and Glu was replaced by a phosphonamidate methyl ester moiety. The amide bond at the end of the acyclic side chain was replaced by a phosphinamide moiety. |
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| Keywords: | bioisosteres immunomodulators phosphopeptides |
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