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ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner
Authors:Thuy P Dao  Brian Martyniak  Ashley J Canning  Yongna Lei  Erica G Colicino  Michael S Cosgrove  Heidi Hehnly  Carlos A Castañeda
Institution:1. Departments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA;2. Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA;3. Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA;4. Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA;5. Department of Biology, Syracuse University, Syracuse, NY 13244, USA;6. Interdisciplinary Neuroscience Program, Syracuse University, Syracuse, NY 13244, USA
Abstract:
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  • Keywords:Corresponding author  liquid-liquid phase separation  ubiquilin-2  ubiquitin  ALS  viscoelasticity  proline-rich  self-assembly  oligomerization  aggregation  protein quality control
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