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Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis
Authors:Yeyun Zhou  Robyn Millott  Hyeong Jin Kim  Shiyun Peng  Ross A Edwards  Tamara Skene-Arnold  Michal Hammel  Susan P Lees-Miller  John A Tainer  Charles FB Holmes  J N Mark Glover
Institution:1. Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada;2. Molecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;3. Department of Biochemistry and Molecular Biology, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada;4. Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Abstract:
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  • Keywords:Corresponding author  iASPP  ASPP2  PP-1c  p53  ANK repeats  RVxF motif  dephosphorylation  SH3  Small angle X-ray scattering  X-ray crystallography
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