New insights into the epigenetics of osteoporosis |
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Authors: | Jean-Guillaume Letarouilly Odile Broux Aline Clabaut |
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Institution: | 1. Univ Lille, EA 4490, PMOI - Physiopathologie des Maladies Osseuses Inflammatoires, F-59000 Lille, France;2. Univ. Littoral Côte d''Opale, EA4490-PMOI, F-62327 Boulogne-sur-Mer, France;3. Service de rhumatologie, Centre Hospitalier Universitaire Régional de Lille, Lille, France |
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Abstract: | Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in the bone marrow compartment. The decrease in bone mass results from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The deficiency of bone cells to replace the resorpted bone can be due to a preferential differentiation of bone marrow stromal cells into adipocytes at the expense of osteoblasts. Consequently, the processes that control the differentiation of osteoclasts, osteoblasts and adipocytes play a crucial role in bone metabolism. It is known that epigenetic mechanisms are critical regulator of the differentiation programs for cell fate and moreover are subject to changes during aging. Here, we summarize recent findings on the role of epigenetics in the modulation of mechanisms that may be associated with osteoporosis. In particular, we focus on disturbances in the bone remodeling process described in human studies that address the epigenetic regulation of the osteoblast/adipocyte balance. |
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Keywords: | Corresponding author at: PMOI ULCO Bassin Napoléon BP 120 F-62327 Boulogne-sur-Mer France Human osteoporosis Epigenetics Osteoblast Osteoclast Adipocyte Differentiation |
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