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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability |
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| Authors: | Charles G Clark Karen A Rossi James R Corte Tianan Fang Joanne M Smallheer Indawati De Lucca David S Nirschl Michael J Orwat Donald JP Pinto Zilun Hu Yufeng Wang Wu Yang Yoon Jeon William R Ewing Joseph E Myers Steven Sheriff Zhen Lou Jeffrey M Bozarth Patrick YS Lam |
| Institution: | Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States |
| Abstract: | |
| Keywords: | Corresponding author Factor XIa inhibitors FXIa Activated partial thromboplastin time aPTT Thrombosis Anticoagulant Bioavailability |
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