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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability |
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| Authors: | Charles G. Clark Karen A. Rossi James R. Corte Tianan Fang Joanne M. Smallheer Indawati De Lucca David S. Nirschl Michael J. Orwat Donald J.P. Pinto Zilun Hu Yufeng Wang Wu Yang Yoon Jeon William R. Ewing Joseph E. Myers Steven Sheriff Zhen Lou Jeffrey M. Bozarth Patrick Y.S. Lam |
| Affiliation: | Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States |
| Abstract: | |
| Keywords: | Corresponding author. Factor XIa inhibitors FXIa Activated partial thromboplastin time aPTT Thrombosis Anticoagulant Bioavailability |
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