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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Authors:Esben Trabjerg  Nadia Abu-Asad  Ziqian Wan  Fredrik Kartberg  Søren Christensen  Kasper D Rand
Institution:1. Protein Analysis Group, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark;2. Biotherapeutic Discovery, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark
Abstract:
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  • Keywords:Corresponding author  Sortilin  membrane receptor  conformational dynamics  ligand binding  HDX-MS  Hydrogen/deuterium exchange mass spectrometry  Structural mass spectrometry
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