Correlating the structure and reactivity of a contact allergen,DNCB, and its analogs to sensitization potential |
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| Authors: | Flora Kimani Seong-Min Kim Rachel Steinhardt Aaron P. Esser-Kahn |
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| Affiliation: | Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States |
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| Abstract: | We report a study that seeks to find a correlation between the overall sensitization potential quantified by the expression of IL-8 by stimulated monocytes and the chemical structure of a model contact allergen, 2,4-dinitrochlorobenzene (DNCB). We show that structure and reactivity of the chemical compounds play an important role in activation of the monocytes and subsequent inflammation in tissue. However, we observed a non-linear correlation between the rate of reaction and biological activity indicating a required balance of stability and reactivity. |
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| Keywords: | Corresponding author. 1-chloro-2,4-dinitrochlorobenzene (DNCB) Structure Activity Relationship (SAR) Interleukin (IL) – 8 Contact hypersensitivity Skin sensitization |
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