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Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity
Authors:Toni I. Gossmann  Achchuthan Shanmugasundram  Stefan Börno  Ludovic Duvaux  Christophe Lemaire  Heiner Kuhl  Sven Klages  Lee D. Roberts  Sophia Schade  Johanna M. Gostner  Falk Hildebrand  Jakob Vowinckel  Coraline Bichet  Michael Mülleder  Enrica Calvani  Aleksej Zelezniak  Julian L. Griffin  Peer Bork  Markus Ralser
Affiliation:1. University of Sheffield, Department of Animal and Plant Sciences, Sheffield S10 2TN, UK;2. Bielefeld University, Department of Animal Behaviour, 33501 Bielefeld, Germany;3. Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK;4. Centre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK;5. Max Planck Institute for Molecular Genetics, Sequencing Core Facility, Ihnestrasse 73, 14195 Berlin, Germany;6. IRHS, Université d’Angers, INRA, Agrocampus-Ouest, SFR 4207 QuaSaV, 49071 Beaucouzé, France;7. BIOGECO, INRA, Université de Bordeaux, 69 Route d''Arcachon, 33612 Cestas, France;8. Department of Ecophysiology and Aquaculture, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, 12587 Berlin, Germany;9. Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK;10. Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK;11. Division of Medical Biochemistry, Medical University of Innsbruck, 6020 Innsbruck, Austria;12. European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany;13. Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, UK;14. Gut Health and Microbes Programme, Quadram Institute, Norwich Research Park, Norwich NR4 7UQ, UK;15. Institute of Avian Research, 26386 Wilhelmshaven, Germany;16. Department of Biochemistry, Charitè, Am Chariteplatz 1, 10117 Berlin, Germany;17. Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden;18. Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm 171 65, Sweden;19. Max-Delbrück-Centre for Molecular Medicine, 13092 Berlin, Germany;20. Molecular Medicine Partnership Unit, 69120 Heidelberg, Germany;21. Université de Lyon, F-69000, Lyon; Université Lyon 1; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, 69622 Villeurbanne, France;22. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
Abstract:
Keywords:Corresponding author  climate adaptation  Alpine marmot  low genetic diversity  NUMT  reference genome  ice age  pleistocene  migration  large population size  lipidomics
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