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Effect of Panax ginseng combined with Angelica sinensis on the dissolution of ginsenosides and in chemotherapy mice hematopoietic function
Authors:Xiaoman Zheng  Zhengfeng Fu  Chunyun Wang  Shengbo Zhang  Min Dai  Enbo Cai  Yan Zhao
Affiliation:1. College of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, China;2. Chongqing Three Gorges Medical College, 366 Tianxing Street, Baianba, Wanzhou District, Chongqing 404120, China
Abstract:ObjectiveTo study the changes of ginsenoside content in different proportion of Panax ginseng-Angelica sinensis (GA) co-decoction, and to explore the amelioration of hematopoietic function in mice after combined use of the two drugs. The active ingredient profiles in P. ginseng single decoction and co-decoction of GA were determined by high performance liquid chromatography (HPLC). The experimental pharmacology method was used to explore the effect of GA co-decoction on the hematopoietic function of chemotherapy mice.ResultsThe active ingredient profiles of the co-decoction of GA significantly changed compared with those of the single decoction. Compared with GA1:0 (single decoction of Panax ginseng), the routine ginsenosides of all proportions of GA decreased significantly, but the proportion of rare ginsenosides increased significantly. The changes of contents of rare ginsenosides of GA were basically consistent with the trends of effects on the myelosuppression induced by CY. Compared with the model group, GA significantly increased the number of bone marrow nucleated cells, thymus index, peripheral blood leukocytes and platelets, and significantly reduced the spleen index. Moreover, GA could promote G1 phase bone marrow cells to enter the cell cycle, increase the proportion of S phase cells and G2/M phase cells, and increase the cell proliferation index.ConclusionGA can ameliorate the hematopoietic function of mice after chemotherapy, and GA2:3, GA3:2 were the best, which may be due to the changes of the pharmacodynamic material basis of GA after compatibility. All these results implied that GA may be an ideal drug and food supplement for the treatment of toxic and side effects of chemotherapeutic drugs.
Keywords:Corresponding authors.  GA  TCM  traditional Chinese medicine  CY  cyclophosphamide  WBC  white blood cells  PLT  platelets  BMNC  bone marrow nucleated cells  Ginsenoside  Myelosuppression  Cyclophosphamide
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