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Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain
Authors:Fabian Gerth  Maria Jäpel  Jana Sticht  Benno Kuropka  Xiao Jakob Schmitt  Jan H Driller  Bernhard Loll  Markus C Wahl  Kevin Pagel  Volker Haucke  Christian Freund
Institution:1. Protein Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany;2. Department of Molecular Pharmacology and Cell Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany;3. Ion Mobility-Mass Spectrometry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany;4. Department of Molecular Physics, Fritz Haber Institute of the Max Planck Society, 14195 Berlin, Germany;5. Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany;6. BioSupraMol Core Facility, Freie Universität Berlin, 14195 Berlin, Germany
Abstract:
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  • Keywords:Corresponding author  synapse  SH3 domain  alternative splicing  autoinhibition  NMR spectroscopy  X-ray crystallography
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