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Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea |
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| Authors: | Nada M Abdel-Wahab Harwoko Harwoko Werner EG Müller Alexandra Hamacher Matthias U Kassack Mostafa A Fouad Mohamed S Kamel Wenhan Lin Weaam Ebrahim Zhen Liu Peter Proksch |
| Institution: | 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany;2. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt;3. Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Jalan dr. Soeparno, Karangwangkal 53123 Purwokerto, Indonesia;4. Institute of Physiological Chemistry, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, 55128 Mainz, Germany;5. Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany;6. Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt;7. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;8. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt |
| Abstract: | Three new cyclic heptapeptides (1–3) together with three known compounds (4–6) were isolated from a solid rice culture of the soil-derived fungus Clonostachys rosea. Fermentation of the fungus on white beans instead of rice afforded a new γ-lactam (7) and a known γ-lactone (8) that were not detected in the former extracts. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. Compounds 1 and 4 exhibited significant cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values of 4.1 and 0.1 µM, respectively. Compound 4 also displayed cytotoxicity against the A2780 human ovarian cancer cell line with an IC50 value of 3.5 µM. The preliminary structure-activity relationships are discussed. |
| Keywords: | Corresponding authors Soil-derived fungus Peptides Cytotoxicity |
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