Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice

Authors:	Menno Hoekstra Joya E. Nahon Laura M. de Jong Mara J. Kröner Lidewij R. de Leeuw Miranda Van Eck

Affiliation:	Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, the Netherlands.

Abstract:

Keywords:	Corresponding author. ABC transporter ATP-binding cassette transporter ACC1 acetyl-CoA carboxylase 1 ADMA asymmetric dimethylarginine ALT alanine aminotransferase ApoE apolipoprotein E cCIMT common Carotid Intima-Media Thickness FAS fatty acid synthase LPL lipoprotein lipase LXR liver X receptor MCP1 monocyte chemoattractant protein 1 oxLDL oxidized LDL PRMT3 protein arginine methyltransferase 3 SDMA symmetric dimethylarginine SREBP-1c sterol regulatory element-binding protein-1c SCD1 stearoyl-coenzyme A desaturase 1 TNFα tumor necrosis factor alpha UCP1 uncoupling protein 1 Protein arginine methyltransferase Atherosclerosis Fatty liver disease Hepatic steatosis Pharmacological inhibition Mouse model
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