Alteration of cardiovascular and neuronal function in M1 knockout mice |
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Authors: | Hamilton S E Hardouin S N Anagnostaras S G Murphy G G Richmond K N Silva A J Feigl E O Nathanson N M |
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Institution: | Department of Pharmacology, University of Washington, Seattle 98195-7750, USA. |
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Abstract: | We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory. |
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