| 比较基因识别-58 |
| |
| 引用本文： | 王鹏源,刘小宇. 比较基因识别-58[J]. 生命的化学, 2012, 0(5): 432-436 |
| |
| 作者姓名： | 王鹏源 刘小宇 |
| |
| 作者单位： | [1]第二军医大学生物化学与分子生物学教研室,上海200433 [2]第二军医大学研究生管理大队学员二队,上海200433 |
| |
| 摘 要： | 比较基因识别-58（comparative gene identification-58，CGI-58）属于脂肪酶家族，是脂肪性甘油三酯脂肪酶的激活蛋白，在调控脂肪代谢方面发挥着至关重要的作用，也是调控角质形成细胞的分化过程的重要分子。另外，CGI-58还具有溶血磷脂酸酰基转移酶活性，可将溶血磷脂酸酰化成磷脂酸。若CGI-58的基因发生突变，会引发一种隐性遗传的中性脂肪蓄积病——Chanarin—Dorfman综合征（Chanarin-Dorfman symptom，CDS），病体表现出鱼鳞病。本文将针对CGI-58调控脂肪代谢以及其它方面的功能，对近些年来CGI-58的研究进展进行综述。
|
| 关 键 词： | CGI-58 ATGL 脂肪代谢 鱼鳞病 |
Research progress of CGI-58 |
| |
| WANG Pengyuan,LIU Xiaoyu. Research progress of CGI-58[J]. Chemistry of Life, 2012, 0(5): 432-436 |
| |
| Authors: | WANG Pengyuan LIU Xiaoyu |
| |
| Affiliation: | 1Departmant of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China 2Squadron 2 of Cadet Brigade, Second Military Medical University, Shanghai 200433, China |
| |
| Abstract: | Comparative gene identification-58 （CGI-58）, the activator of the adipose triglyceride lipase, belongs to α/β-hydrolase family of proteins, and is crucial for the regulation of adipose metabolism. It is also an important molecule participating in the differentiation of keratinocyte. Furthermore, CGI-58 acts as the lysophosphatidic acid acyltransferase mediating the acylation of lysophosphatidic acid to phosphatidic acid. CGI-58 mutation may result in Chanarin-Dorfman symptom, a recessive inheritant neutral-lipid-storage disease charactered by epidermic ichthyosis. This paper reviewed the recent research progress of CGI-58 focusing on its regulation for adipose metabolism and other functions. |
| |
| Keywords: | CGI-58 ATGL adipose metabolism ichthyosis |
| 本文献已被 维普 等数据库收录！ |
|
