人乳头瘤病毒次要衣壳蛋白L2核定位

在人乳头瘤病毒(human papillomavirus,HPV)次要衣壳蛋白L2的N端和C端,有大量带正电荷的氨基酸残基组成核定位信号(nuclear localization signal,NLS)。细胞的核结构域10(nuclear domain 10,ND10)是细胞周期和病毒生活周期的重要调节者。L2定位到ND10的过程不仅会受到早幼粒细胞白血病蛋白(promyleocytic leukaemia protein,PML)、死亡结构域相关蛋白(deathdomain-associated protein,Daxx)、Sp100核抗原(Sp100 nuclear antigen)等细胞蛋白的影响,也会与L1在ND10发生相互作用。在HPV感染和组装过程中,L2的核定位信号有着重要作用。

Nucleic localization of human papillomavirus minor capsid protein L2

The nuclear localization signal, NLS, which is composed of many amino acids with positive charge residue, is located in both ends of N terminus and C terminus of the human papillomavirus minor capsid protein L2. The nuclear domain 10, ND-10, which is in the cell nucleus, is an important modulator of both cell cycle and virus cyclogeny. The process of the locating of L2 to ND-10, is not only impacted by the cell proteins, such as the promyelocytic leukemia protein, death domain-associated protein Daxx, nuclear antigen Sp 100, but also interacts with L1 in ND-10. The NLS of L2 plays a significant role during the HPV virus assembly course.