| 化学基因组学和化学蛋白质组学用于细胞自噬研究 |
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| 引用本文： | 罗继壮,苗俊英. 化学基因组学和化学蛋白质组学用于细胞自噬研究[J]. 生命的化学, 2012, 0(5): 471-475 |
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| 作者姓名： | 罗继壮 苗俊英 |
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| 作者单位： | 山东大学生命科学学院,济南250100 |
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| 基金项目： | 国家级大学生创新创业训练计划（1110422025）资助 |
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| 摘 要： | 化学基因组学和化学蛋白质组学作为后基因组时代的新技术，是以化学小分子为工具，对细胞的生理过程进行精确干扰，研究有机体和细胞的功能，同时也是新药开发的重要手段。本文综述了化学基因组学和化学蛋白质组学征自噬相关靶点的特异性小分子的发现，及小分子存自噬机理研究中的应用。
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| 关 键 词： | 化学基因组学 化学蛋白质组学 化学遗传学 自噬 小分子 |
Application of chemical genomics and chemical proteomics methods in research of autophagy mechanism |
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| LUO Jizhuang,MIAO Junying. Application of chemical genomics and chemical proteomics methods in research of autophagy mechanism[J]. Chemistry of Life, 2012, 0(5): 471-475 |
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| Authors: | LUO Jizhuang MIAO Junying |
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| Affiliation: | School of Life science, Shandong University, Ji＇nan 250010, China |
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| Abstract: | As new technologies in post-genome era, chemical genomics and chemical proteomics utilize small molecules as tools to accurate interference the physiological processes of cells and conduct researches on functions of organisms and cells. Meanwhile, they are important techniques for the development of new drugs. This review includes the progress for the application of chemical genomics and chemical proteomics tools on the discovery of small molecule chemicals specific for autophagy related targets and inducers of autophagy, as well as the application of the small molecules to the autophagy mechanism research. |
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| Keywords: | chemical genomics chemical proteomics chemical genetics autophagy small molecule |
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