Conversion of versiconal acetate to versiconal and versicolorin C in extracts from Aspergillus parasiticus |
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Authors: | John A. Anderson Chang Ho Chung |
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Affiliation: | (1) Department of Chemistry and Biochemistry, Texas Tech University, 79409 Lubbock, TX, USA;(2) Present address: Department of Biochemistry, Michigan State University, 48824-1319 East Lansing, MI, USA |
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Abstract: | The primary product of hydrolysis of versiconal acetate catalyzed by porcine liver esterase and the 35–70% ammonium sulfate fraction from a soluble extract from mycelia of Aspergillus parasiticus was versiconal. Versiconal was stable at neutral pH for several hours and was rapidly converted to versi-colorin C by treatment with 0.4 M HCl. The addition of NADPH to the 35–70% ammonium sulfate fraction resulted in conversion of versiconal acetate to both versiconal and versicolorin C. The conversion of versiconal acetate to versicolorin C in the cell-free system is proposed to involve an esterase and an NADPH-dependent cyclase. |
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Keywords: | versiconal aflatoxin Aspergillus versicolorin C |
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