Adherence and biofilm formation of non-Candida albicans Candida species |
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Authors: | Silva Sónia Negri Melyssa Henriques Mariana Oliveira Rosário Williams David W Azeredo Joana |
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Affiliation: | 1 Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar 4710-057, Braga, Portugal;2 Tissue Engineering and Reparative Dentistry, School of Dentistry, Heath Park, Cardiff CF14 4XY, UK |
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Abstract: | Most cases of candidosis have been attributed to Candida albicans, but recently non-C. albicans Candida species have been identified as frequent human pathogens. Candida pathogenicity has been attributed to several factors, including adhesion to medical devices and/or host cells, biofilm formation, and secretion of hydrolytic enzymes (proteases, phospholipases and haemolysins). Although 'new'Candida species are emerging, there is still a lack of information about their pathogenicity. This review discusses recent advances in our knowledge of Candida glabrata, Candida parapsilosis and Candida tropicalis virulence factors, specifically those of adhesion and biofilm formation, which are key components in Candida pathogenicity. |
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