Studies on plasma membranes. XXIII. Hormone-like action of concanavalin A on liver plasma membranes: inhibition of (Na+-K+)ATPase. |
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Authors: | P Luly P Emmelot |
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Institution: | Department of Biochemistry, Antoni van Leeuwenhoek-Laboratory, The Netherlands Cancer Institute, Amsterdam The Netherlands |
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Abstract: | Concanavalin A inhibits the (Na+-K+)-ATPase activity of isolated rat-liver plasma membranes, while leaving the Mg2+-ATPase unaffected. Glucagon and cyclic AMP act supplementary to the lectin in the inhibition. The lectin effect is counteracted by insulin and L-epinephrine, and is completely abolished by the beta-adrenergic blocking agent propranolol. Results are discussed on the basis of the known interactions of concanavalin A with plasma membrane components, including its hormone-like action. |
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Keywords: | To whom reprint requests should be directed at the postal address of the Antoni van Leeuwen-hoek-Laboratory 108 Sarphatistraat Amsterdam The Netherlands |
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