The pinwheel experiment re-revisited. |
| |
Authors: | Alexandre Sambelashvili Igor R Efimov |
| |
Institution: | Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, U.S.A. |
| |
Abstract: | Virtual electrode induced phase singularity hypothesis explains the origin of cardiac arrhythmias caused by artificial electrical induction of rotors, i.e. vortex-like self-sustained sources of activity. This mechanism is thought to underlie both stimulus-induced arrhythmias and shock defibrillation therapy. In this paper, we extend this hypothesis to three dimensions using the bidomain model of cardiac tissue. We predict that virtual electrode polarization can produce three topologically distinct types of rotors anchored to: (1) transmural I-shaped scroll wave filaments; (2) near-surface U-shaped scroll wave filaments; and (3) intramural O-shaped scroll wave filaments. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|