Alteration of biliary ursodeoxycholic acid in guinea pig during early stages of cholestyramine feeding |
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Authors: | Job R Li Dac M Dinh Bruce A Kottke |
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Institution: | 1. Cardiovascular Research Unit, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901 USA;1. Northwest Lipid Research Clinic, Harborview Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104 USA |
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Abstract: | The effects of cholestyramine feeding on biliary ursodeoxycholic acid, fecal excretion of bile acids and neutral sterols on cholesterol 7α-hydroxylase and hepatic HMG-CoA reductase were examined in the guinea pig. In the bile there was a 57% decrease in the concentration of ursodeoxycholic acid while an increase was observed in the concentration of chenodeoxycholic acid. Cholestyramine feeding for ten days resulted in a decrease in plasma cholesterol levels and an increase in both hepatic HMG-CoA reductase and cholesterol 7α-hydroxylase activities. The fecal excretion of both bile acids and neutral sterols was significantly increased. |
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Keywords: | HMG-CoA Reductase 3-hydroxy-3-methylglutaryl CoA Reductase |
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