Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers |
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Authors: | Enrique Sánchez-Molano John A Woolliams Ricardo Pong-Wong Dylan N Clements Sarah C Blott Pamela Wiener |
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Affiliation: | .The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG Scotland, UK ;.Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG Scotland, UK ;.Kennel Club Genetics Centre at the Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU UK ;.School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, LE12 5RD UK |
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Abstract: | BackgroundCanine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).ResultsTwo genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.ConclusionConsistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-15-833) contains supplementary material, which is available to authorized users. |
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Keywords: | Canine hip dysplasia Labrador Retriever Norberg Angle QTL GWAS Genomic selection |
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