Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition |
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| Authors: | R Pinkas-Kramarski R Stein Y Zimmer M Sokolovsky |
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| Affiliation: | Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel. |
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| Abstract: | Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed. |
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